Andrographis: Benefits, Properties and Ultra-Complete User Guide

Table of Contents

1. Introduction and History

2. Botanical portrait and chemical composition

3. Scientifically proven benefits

4. Andrographis and the immune system: regulation of the NF-κB factor

5. Clinical studies and scientific validations

6. Forms, dosages and methods of use

7. Precautions, contraindications and side effects

8. Specific applications

9. Purchasing advice and quality criteria

10. FAQ: Your questions about Andrographis

11. About the author

1. Introduction and History.

Andrographis paniculata, often referred to as the "King of Bitters", is a medicinal plant whose exceptional virtues have fascinated health practitioners for over 2000 years. Used in Ayurvedic medicine in India and in Traditional Chinese Medicine (TCM), it is renowned for its ability to strengthen immunity, fight infections and reduce inflammation. This plant is particularly prized for its richness in andrographolides, bioactive compounds that explain its multiple therapeutic benefits. It is now widely studied for its potential to support overall health, prevent chronic diseases and improve the body's resilience to external aggressions.

A long history of medicinal use.

• In India : Used in Ayurvedic medicine to purify the blood, improve digestion, treat fever and prevent viral and bacterial infections. Andrographis is often incorporated into complex preparations aimed at balancing the doshas, ​​the vital energies of the body according to Ayurveda.
  
  

• In China : Known as Chuan Xin Lian, it is incorporated into traditional remedies to treat respiratory infections, tonsillitis, bronchitis, digestive disorders and even some skin diseases. TCM practitioners often use it in combination with other herbs to potentiate its effects.
  
  

• In Thailand and Sri Lanka : Consumed as a bitter decoction to relieve stomach aches, stimulate the appetite, and reduce tropical fever. In these regions, Andrographis is often grown locally and used daily for its medicinal properties.
  
  

Modern scientific recognition.

Over the decades, Andrographis has attracted the attention of researchers for its impressive pharmacological properties. Hundreds of clinical studies have validated its effects on the immune system, its ability to reduce chronic inflammation, and its potential to treat autoimmune diseases such as rheumatoid arthritis or ulcerative colitis. Researchers have also explored its role in modulating immune responses, particularly in the regulation of pro-inflammatory cytokines.

👉 Notable fact : In 2021, the World Health Organization (WHO) officially recognized Andrographis for its effectiveness in the prevention and treatment of uncomplicated acute respiratory infections—a validation that places the herb in the spotlight of modern integrative medicine. This recognition has encouraged wider use of Andrographis in conventional healthcare systems, as a complement to existing treatments.

2. Botanical portrait and chemical composition.

Andrographis paniculata is a herbaceous plant belonging to the Acanthaceae family. It grows mainly in tropical and subtropical regions of Asia, where it thrives at temperatures between 20 and 30°C. This plant is often grown in humid and shaded environments, which favors its growth and the concentration of its active ingredients.

Botanical characteristics.

• Height : Approximately 30 to 110 cm. Plant size may vary depending on growing conditions and soil quality.

• Leaves : Green, lanceolate, long and thin. The leaves are often harvested for their medicinal properties.

• Flowers : White with purple spots. Flowers usually appear in clusters and are small but distinctive.

• Parts used : Leaves and stems (richest in active ingredients). The roots can also be used in certain traditional preparations.

The active ingredients responsible for the benefits.

Andrographis owes its therapeutic power to a unique chemical composition, comprising several classes of bioactive compounds:

• Andrographolide : A major diterpenoid with potent anti-inflammatory, antiviral and immunomodulatory effects. It inhibits biochemical pathways involved in the production of pro-inflammatory cytokines such as TNF-α and IL-6. Andrographolide is the most studied compound of the plant and is often used as a quality marker in standardized extracts.
  
  

• Neoandrographolide : Known for its antioxidant properties, it helps reduce oxidative stress and protects cells from free radical damage. This compound is also involved in the modulation of immune responses.
  
  

• 14-deoxy-11,12-didehydroandrographolide : Modulating immune and inflammatory responses, this compound helps calm excessive inflammation. It works synergistically with other compounds to enhance the therapeutic effects of Andrographis.
  
  

• Flavonoids : Antioxidants that protect cells and enhance blood circulation. The flavonoids present in Andrographis also contribute to its anti-inflammatory properties.
  
  

• Phytosterols : Contribute to the reduction of cholesterol and support cardiovascular health. Phytosterols are natural compounds found in many plants and are known for their beneficial effects on the cardiovascular system.
  
  

👉 Note : Andrographis extracts are often standardized to ensure an optimal concentration of andrographolides (between 10% and 50%). The higher the concentration, the more pronounced the therapeutic effects. Standardized extracts are preferred in clinical applications to ensure consistent efficacy and safety.

A single profile for multiple effects.

This synergy of bioactive compounds gives Andrographis a global therapeutic action: it acts not only on immunity, but also on inflammation, hepatic detoxification, cellular protection and even bone metabolism. Andrographis is therefore a versatile plant that can be used in various therapeutic contexts, ranging from the prevention of infections to the support of chronic disease treatments.

3. Scientifically proven benefits

Andrographis paniculata has been the subject of numerous scientific studies that have confirmed its multiple health benefits. Among the most documented effects, we find:

• Strengthening the immune system : Andrographis stimulates the production of white blood cells and improves the immune response to infections. It is particularly effective in preventing and treating respiratory infections, such as colds and flu.
  
  

• Reduction of inflammation : The active compounds in Andrographis, including andrographolide, inhibit the production of pro-inflammatory cytokines, thereby reducing chronic inflammation associated with various diseases, such as arthritis and inflammatory bowel disease.
  
  

• Antiviral and antibacterial properties : Andrographis has demonstrated antiviral activity against several viruses, including those responsible for influenza and herpes. It also possesses antibacterial properties, making it a versatile therapeutic agent.
  
  

• Liver Protection : The antioxidant compounds in Andrographis protect the liver from oxidative damage and promote detoxification. It is often used in the treatment of liver diseases, such as hepatitis.
  
  

• Improved Digestion : Andrographis stimulates the production of bile and improves digestion, thereby relieving digestive disorders such as dyspepsia and stomach aches.
  
  

• Potential anticancer effects : Preliminary studies suggest that Andrographis may have anticancer effects by inhibiting cancer cell proliferation and inducing apoptosis, programmed cell death.
  
  

4. Andrographis and the immune system: regulation of the NF-κB factor

One of the most studied mechanisms of action of Andrographis is its ability to regulate the transcription factor NF-κB, a key regulator of the immune response and inflammation. NF-κB plays a central role in the production of pro-inflammatory cytokines, and its regulation is essential to prevent excessive inflammatory responses.

Andrographolide, the main active compound in Andrographis, inhibits NF-κB activation by interacting with signaling proteins involved in its activation. This inhibition reduces the production of pro-inflammatory cytokines such as TNF-α and IL-6, which helps to attenuate inflammation and protect tissues from damage.

5. Clinical studies and scientific validations.

The benefits of Andrographis have been validated by numerous clinical studies. For example, a meta-analysis of several clinical trials showed that Andrographis was effective in reducing the duration and severity of cold and flu symptoms. Other studies have demonstrated its effectiveness in the treatment of acute respiratory infections, digestive disorders and chronic inflammatory diseases.

Clinical studies have also explored the safety of Andrographis, confirming that it is generally well tolerated with few side effects when used at therapeutic doses. However, as with any herbal remedy, it is important to consult a healthcare professional before using it, particularly if you are taking other medications or have pre-existing medical conditions.

6. Forms, dosages and methods of use.

Andrographis is available in several forms, including capsules, tablets, tinctures, liquid extracts, and powders. Dosages may vary depending on the form and concentration of active ingredients.

• Capsules and tablets : Common doses range from 400 to 600 mg, two to three times daily. Extracts standardized to andrographolides are preferred to ensure consistent efficacy.

• Tinctures and liquid extracts : Typically taken 1 to 2 ml, three times daily, diluted in water. Alcoholic tinctures are often more concentrated and may be more effective for some uses.

• Powders : Can be mixed with water or juice and consumed at a rate of 1 to 2 grams per day. Powders are often used in traditional preparations.

7. Precautions, contraindications and side effects.

Although Andrographis is generally considered safe, there are some precautions that should be taken:

• Pregnant and lactating women : Andrographis should be avoided during pregnancy and lactation due to lack of data on its safety.

• People with autoimmune diseases : Andrographis may stimulate the immune system, which could worsen symptoms of autoimmune diseases.

• Drug Interactions : Andrographis may interact with certain medications, including immunosuppressants and blood thinners. It is important to consult a healthcare professional before use if you are taking other medications.

Possible side effects include stomach upset, nausea, vomiting, and allergic reactions. These effects are generally rare and may be lessened by taking Andrographis with food.

8. Specific applications.

Andrographis can be used in various therapeutic contexts:

• Prevention and treatment of respiratory infections : Used to reduce the duration and severity of symptoms of colds, flu, and acute respiratory infections.

• Digestive Disorders Management : Effective in relieving stomach upset, dyspepsia and mild digestive disorders.

• Immune System Support : Used to boost immunity and prevent infections, especially during times of stress or fatigue.

• Treatment of chronic inflammatory diseases : Used in addition to conventional treatments to reduce inflammation associated with diseases such as arthritis and inflammatory bowel disease.

9. Purchasing advice and quality criteria.

When purchasing Andrographis products, it is important to look for extracts that are standardized to andrographolides, with the concentration clearly stated on the label. High-quality products should also be free of contaminants and come from reputable sources.

• Check standardization : Make sure the product is standardized to andrographolides, with a concentration of at least 10%.

• Read labels : Look for products without artificial additives, preservatives or fillers.

• Choose reputable brands : Opt for brands known for their commitment to quality and purity of ingredients.

The Andrographis Paniculata 500 mg 60 capsules supplement is the product we recommend if you choose this plant. It is known to be safe and effective.

10. FAQ: your questions about Andrographis.

• What is the recommended dose of Andrographis?
  
  

• Common doses range from 400 to 600 mg, two to three times a day, depending on the form and concentration of active ingredients.

• Is Andrographis safe for long term use?
  
  

• Andrographis is generally safe for short-term use. For long-term use, it is recommended to consult a healthcare professional.

• Can I use Andrographis if I am pregnant?
  
  

• Andrographis should be avoided during pregnancy and breastfeeding due to lack of data on its safety.

11- About the author:

Marie Gautier is a dietician and consultant specializing in naturopathy and alternative medicine, practicing with passion for more than 15 years at the Pleine Forme store in Tours. With her experience and expertise, Marie has built a solid reputation in the field of natural health. She is dedicated to helping her clients achieve optimal well-being through holistic and natural approaches.

Marie Gautier is a true reference in the advice of food supplements in Tours, and her expertise continues to inspire those who seek to improve their health naturally.