Natural Anti-inflammatory Agents: Which Ones to Choose and How to Really Use Them?

Article written by Marie Gautier, certified dietitian – 16 years of expertise | Last updated: May 2026

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Introduction: What if that dull fatigue was hiding silent inflammation?

You wake up in the morning with stiff joints. Not really painful, just heavy, like they’re rusty. You’ve had fluctuating energy levels for months. You digest poorly, your skin feels tight, and you feel like you recover more and more slowly after the slightest effort.

Your doctor found nothing alarming. The tests are "within normal limits." And yet, you feel that something is wrong.

This scenario is one I encounter very frequently in my practice. And one of the first avenues I explore with my clients in this case is low-grade chronic inflammation, a silent, diffuse inflammation that standard tests don't always pick up, but which gradually wears down the body over time.

The good news? There are natural agents remarkably well-documented to modulate this inflammation. Not to suppress it at all costs, because acute inflammation is a useful defense mechanism. But to soothe it when it flares up, when it becomes chronic, when it quietly settles in and sabotages your daily life.

Take stock. Check what applies to you:

• ☐ You experience chronic joint or muscle pain, even mild
• ☐ You are often tired for no clear reason, especially at the beginning of the day
• ☐ You have reactive skin, recurring eczema or psoriasis
• ☐ You digest poorly, with regular bloating and a sensitive stomach
• ☐ You easily catch infections or recover slowly
• ☐ You have gradually gained weight despite a stable diet
• ☐ You experience bursts of irritability or mood swings without explanation

If you recognize yourself in 3 or more boxes, this article is for you.

Because behind each of these signals can hide poorly regulated chronic inflammation, and because there are, in nature, remarkably effective molecules to address it. Agents you can integrate into your diet, your routine, your supplement strategy without the side effects of conventional anti-inflammatories, and without sacrificing your quality of life.

We will review them together, with supporting scientific evidence, and a concrete protocol to get started today.

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What is chronic inflammation and why should you take it seriously?

Inflammation is, at its core, a survival mechanism. When you cut your finger or catch a virus, your immune system triggers an inflammatory response to neutralize the threat and repair tissues. This is useful. It's even vital.

The problem is when this response doesn't switch off.

Low-grade chronic inflammation is a persistent, low-intensity inflammation without an identifiable pathogen. It is often invisible to the naked eye and to standard tests. Yet, it is now identified as a common underlying factor in many pathologies: cardiovascular diseases, type 2 diabetes, autoimmune disorders, depression, cognitive decline, cancers.

The 4 key mechanisms of chronic inflammation

1. Persistent activation of NF-κB: this pro-inflammatory transcription factor orchestrates the inflammatory response. When it gets out of control, it triggers a cascade of pro-inflammatory cytokine production (TNF-α, IL-1β, IL-6)

2. Oxidative stress: excess free radicals damage cells and fuel inflammation. A diet poor in antioxidants amplifies this vicious circle

3. Intestinal dysbiosis: an imbalanced microbiota increases intestinal permeability (leaky gut), allowing bacterial fragments (LPS) to pass into the bloodstream, which constantly activates the immune system

4. HPA axis dysregulation: chronic stress elevates cortisol over time, which paradoxically ends up reducing tissue sensitivity to glucocorticoids and thus amplifying inflammation

The main causes of chronic inflammation today

• Ultra-processed diet, rich in refined sugars, trans fats, and excess omega-6s
• Prolonged sedentary lifestyle
• Unmanaged chronic stress
• Overweight and excess visceral adipose tissue (abdominal fat is itself pro-inflammatory)
• Lack of sleep (less than 6 hours per night increases inflammatory markers after just 1 week)
• Smoking, excessive alcohol
• Environmental pollution

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Foods that naturally fight inflammation

Diet is the most powerful and direct lever for modulating inflammation. Here are the best-documented food agents.

Polyphenols: The ultimate anti-inflammatory antioxidants

Resveratrol (red grapes, blueberries, mulberries, peanuts) Resveratrol inhibits NF-κB and COX-2 (a pro-inflammatory enzyme), two major targets of inflammation. It is particularly concentrated in the skin of red grapes and wild blueberries.

Anthocyanins (red fruits: cherries, raspberries, blueberries, pomegranate) These red and purple pigments reduce CRP levels (C-reactive protein, an inflammation marker) and inhibit the production of pro-inflammatory cytokines. A handful of red fruits a day is simple and delicious.

Quercetin (red onion, capers, apple with skin, broccoli) A powerful natural anti-inflammatory and antihistamine. It inhibits histamine release and reduces inflammatory markers. Raw red onion in salad is one of the best dietary sources.

EGCG (epigallocatechin gallate, green tea) The most active polyphenol in green tea modulates NF-κB and reduces pro-inflammatory cytokines. 2 to 3 cups of green tea per day constitute a relevant dose.

Turmeric and ginger: The go-to anti-inflammatory duo

Active Ingredient	Source	Main Mechanism	Absorption Tip
Curcumin	Turmeric (yellow root)	Inhibits NF-κB, COX-2, TNF-α	Always with black pepper (piperine) and fat
Gingerol / Shogaol	Fresh or dried ginger	Inhibits prostaglandins, reduces IL-6	Fresh grated in hot dishes or infusions

In the kitchen: a golden latte in the morning (plant milk + turmeric + ginger + black pepper + coconut oil) is one of the best ways to consume these two active ingredients together.

Omega-3s: The fats that extinguish inflammation

Omega-3 fatty acids, particularly EPA and DHA, are precursors of resolvins and protectins, molecules that actively resolve inflammation. Conversely, excess omega-6s (sunflower, corn, soy oils, processed foods) are pro-inflammatory.

Best dietary sources of omega-3s:

• Wild fatty fish: sardines, mackerel, herring, wild salmon (2 to 3 servings per week)
• Walnuts (2.5g ALA per 30g)
• Ground flax seeds (2.3g ALA per tablespoon)
• Chia seeds (5g ALA per 30g)
• Rapeseed oil (cold-pressed, for dressing only)

Ideal omega-6 / omega-3 ratio: between 3:1 and 5:1. The French average is currently around 15:1, a major imbalance that fuels chronic inflammation.

Cruciferous vegetables: Sulforaphane, the discreet anti-inflammatory

Sulforaphane, concentrated in broccoli, Brussels sprouts, cauliflower, and kale, activates the Nrf2 pathway, a major regulator of cellular antioxidant and anti-inflammatory defenses. To maximize its content, cut broccoli 40 minutes before cooking it (this activates the enzyme myrosinase) and consume it lightly steamed, never boiled.

Foods to absolutely reduce

• Refined sugars and high glycemic index foods: each glycemic peak triggers an inflammatory wave via NF-κB activation
• Trans fats (hard margarines, industrial fried foods, pastries): directly pro-inflammatory
• Excess alcohol: increases intestinal permeability and inflammatory cytokines
• Oils rich in omega-6s (sunflower, corn, soy) for high-temperature cooking
• Processed red meats (cold cuts, smoked meats): rich in nitrites and pro-inflammatory saturated fats

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Consumption habits that maximize the anti-inflammatory effect

Antioxidant timing

Polyphenols are better absorbed in the presence of fats. Systematically combine:

• Turmeric + olive oil + black pepper
• Red fruits + whole yogurt or almonds
• Green tea + a few walnuts

Intermittent fasting: an underestimated anti-inflammatory tool

Studies published in Cell and Nature Reviews Immunology show that intermittent fasting (16:8) significantly reduces inflammatory markers, especially CRP and IL-6. Even a 12-hour window without eating (dinner at 7 pm, breakfast at 7 am) begins to produce positive effects on inflammation.

Cooking: preserve anti-inflammatory active ingredients

• Gentle steaming: ideal for preserving polyphenols and vitamin C
• High-heat wok cooking: acceptable for vegetables, quick and without overheating
• To avoid: repeated frying, high-temperature cooking in oils rich in omega-6s
• Recommended cooking oils: virgin coconut oil or ghee for hot cooking; extra virgin olive oil for dressing only (do not heat above 180°C)

Eat colorful, eat diverse

The simplest and most effective rule: the more colorful your plate, the richer it is in anti-inflammatory polyphenols. Green (broccoli, spinach), red (tomatoes, peppers, cherries), orange (carrots, turmeric), purple (blueberries, red onion, red cabbage). Aim for at least 5 different colors per day.

Hydration and inflammation

Chronic dehydration increases the concentration of circulating toxins and aggravates cellular inflammation. Aim for 1.5 to 2 liters of water per day and consider ginger-turmeric infusions or green tea as a liquid anti-inflammatory bonus.

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Lifestyle habits that amplify the effect of anti-inflammatory agents

Physical exercise: the most powerful anti-inflammatory there is

Moderate and regular physical activity is the most effective anti-inflammatory intervention known to date. It reduces CRP, IL-6, and TNF-α, while increasing anti-inflammatory adipokines (adiponectin).

Concrete recommendations:

• Brisk walking or cycling: 30 to 45 minutes, 5 times a week. This is the basic, accessible to everyone
• Yoga or tai chi: 2 sessions per week. Reduce cortisol and inflammatory markers measurably
• Light strength training: 2 to 3 sessions per week. Reduces visceral adipose tissue, which is itself pro-inflammatory
• Beware of excess: intense training without sufficient recovery temporarily increases inflammation. Dose intelligently

In my practice, I have seen people suffering from chronic joint pain regain remarkable mobility in 8 weeks, simply by combining 30 minutes of daily walking, turmeric, and omega-3s. It's not spectacular to tell. But it's real.

Sleep: the night repairs what the day damages

During deep sleep, the body produces anti-inflammatory cytokines and repairs damaged tissues. Less than 6 hours of sleep for one week is enough to double CRP levels, according to a study published in Sleep (Meier-Ewert et al., 2004).

To implement:

• Go to bed at a fixed time, ideally before 11 pm
• Aim for 7 to 9 hours of restorative sleep
• Room temperature: 18 to 19°C
• Total darkness (or sleep mask)
• Avoid screens 60 minutes before bedtime

Stress management: turning off the inflammatory tap

Chronic stress is one of the most powerful activators of inflammation via the HPA axis and cortisol production. Without active stress management, all your dietary efforts will be partially sabotaged.

What works long-term:

• Heart coherence: 3 times a day, 5 minutes. Reduces cortisol by 15 to 20% in a few weeks
• Mindfulness meditation: 10 to 20 minutes daily with apps like Petit Bambou, Headspace or Waking Up
• Progressive cold shower (30-second cold shower at the end of the shower): activates the parasympathetic nervous system and reduces pro-inflammatory cytokines
• Journaling: 5 minutes in the evening to externalize ruminations and reduce stress system activation

Reduce exposure to environmental toxins

Endocrine disruptors (BPA, phthalates, pesticides) activate inflammatory pathways. Some concrete actions:

• Prefer glass or stainless steel containers
• Eat organic food for the "dirty dozen" (strawberries, spinach, apples, grapes…)
• Air out your home for 10 minutes mornings and evenings
• Avoid aggressive chemical cleaning products (white vinegar + baking soda work very well)

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The most effective anti-inflammatory dietary supplements

1. Curcumin (standardized turmeric extract)

The most studied natural anti-inflammatory active ingredient in the world, with more than 12,000 studies published on PubMed. It simultaneously inhibits NF-κB, COX-2, LOX-5, and numerous pro-inflammatory cytokines.

Dosage: 500 to 1,000 mg/day of standardized extract with 95% curcuminoids, always combined with piperine (20 mg), which multiplies absorption by 20. To be taken with a meal containing fats.

At Pleine Forme, we offer a natural formula, dosed for optimal effectiveness — see our anti-inflammatory supplement.

                     

2. Omega-3s (EPA/DHA — fish or algal oil)

EPA and DHA fatty acids are precursors of resolvins, protectins, and maresins—molecules that actively resolve inflammation, not just block it. This is a fundamental difference from conventional anti-inflammatories.

Dosage: 2 to 3 g of EPA+DHA per day for a clinically relevant anti-inflammatory effect. Choose fish oil from small wild fish (sardines, anchovies) or algal oil for vegetarians, with a TOTOX index below 26.

See the supplement.

3. Boswellia serrata (Indian frankincense)

Less known than curcumin but just as well-documented. Boswellia inhibits 5-LOX (5-lipoxygenase), a pro-inflammatory enzyme distinct from COX-2, making it an ideal supplement to combine with curcumin for a more complete action.

Particularly effective for joint pain and connective tissue inflammation.

Dosage: 300 to 500 mg of standardized extract with 65% boswellic acids (AKBA), 2 to 3 times a day. Effects are felt after 4 to 6 weeks.

View supplement.

4. Resveratrol

Potent activator of SIRT1 sirtuin and NF-κB inhibitor. It modulates chronic inflammation and has documented anti-aging properties in the context of high oxidative stress.

Dosage: 150 to 500 mg/day of trans-resveratrol (active form), preferably in the morning on an empty stomach or with a light meal. Bioavailability is low outside of lipid or liposomal formulations.

View resveratrol supplement.

5. Quercetin

Particularly indicated in cases of allergic or intestinal inflammation. Quercetin stabilizes mast cells, reduces histamine release, and inhibits the production of pro-inflammatory cytokines.

Dosage: 500 to 1,000 mg/day, preferably combined with bromelain (an enzyme from pineapple that improves its absorption) and vitamin C.

View Quercetin supplement.

6. Vitamin D3 (at corrective doses if deficient)

Vitamin D is much more than a vitamin for bones; it is a powerful immune modulator and anti-inflammatory. A vitamin D deficiency (< 30 ng/mL) is associated with high levels of CRP and IL-6.

Dosage: Have your 25-OH vitamin D measured before supplementing. In case of deficiency: 2,000 to 4,000 IU/day of D3 (cholecalciferol), ideally combined with vitamin K2-MK7 to direct calcium to the bones and not to the arteries.

View Vitamin D3 supplement.

7. Blackcurrant Extract (Ribes nigrum)

Less publicized than turmeric, blackcurrant extract is nevertheless one of the most interesting anti-inflammatory active ingredients in European phytotherapy — and one of the best tolerated. In my practice, I recommend it more and more, especially to people who do not tolerate curcumin or who are looking for a complementary active ingredient for joint and muscle pain.

Why blackcurrant? Its leaves and berries are naturally rich in anthocyanins (the black-purple pigments), quercetin, vitamin C, and gamma-linolenic acids (GLA). Together, these compounds act on several inflammatory pathways simultaneously:

• Blackcurrant anthocyanins inhibit COX-1 and COX-2 — the same enzymes targeted by conventional anti-inflammatory drugs like ibuprofen — without the associated gastric side effects
• GLA, a precursor to anti-inflammatory prostaglandins of series 1, modulates the pro-inflammatory arachidonic cascade
• Quercetin reduces histamine release and stabilizes mast cells, making it a valuable ally in cases of allergic inflammation
• Endogenous vitamin C enhances antioxidant action and potentiates collagen synthesis around inflamed joints

A study published in Phytotherapy Research (Garbacki et al., 2004) showed that blackcurrant leaf extract significantly reduced inflammatory markers and improved joint comfort in patients with osteoarthritis. More recent work confirms its action on the inhibition of TNF-α and IL-6, two major pro-inflammatory cytokines.

A "drainage + anti-inflammatory" active ingredient with a double effect

One of the often-overlooked benefits of blackcurrant is its gentle draining and diuretic action. The elimination of metabolic waste — particularly uric acid — plays an important role in managing joint inflammation. Blackcurrant therefore acts on two levels: it reduces active inflammation and promotes the elimination of toxins that maintain it. A rare combination in a single active ingredient.

Available forms:

• Blackcurrant leaf extract (capsules or liquid extract): the most studied form for its joint anti-inflammatory effect
• Blackcurrant berry juice or powder: rich in anthocyanins, more accessible, to be incorporated into the daily diet
• Blackcurrant bud (gemmotherapy, glycerin macerate): used in phytotherapy for its natural "cortisone-like" properties — it stimulates the production of endogenous cortisol, supporting the body's natural anti-inflammatory response

Dosage:

• Standardized leaf extract: 200 to 400 mg/day, in 2 doses with meals
• Bud macerate (gemmotherapy 1D): 5 to 15 drops, 1 to 3 times a day before meals
• Pure blackcurrant juice (unsweetened): 50 to 100 ml per day, as a dietary supplement

For whom? Blackcurrant is particularly recommended for chronic joint pain, gout or elevated uric acid, inflammation associated with retention or poor elimination, and for people who want a very well-tolerated approach suitable for long-term use.

Winning combinations: blackcurrant + boswellia (double COX/LOX inhibition), blackcurrant + nettle (remineralization + drainage), blackcurrant + curcumin (versatile anti-inflammatory synergy).

View Blackcurrant supplement.

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Your complete protocol: 30-day anti-inflammatory action plan

Week 1: Reduce pro-inflammatories, lay the groundwork

Goal: eliminate the main fuels of inflammation

• Eliminate sunflower and corn oils from your kitchen (replace with olive oil and coconut oil)
• Remove added sugars and ultra-processed foods (read labels)
• Introduce the morning golden latte: plant milk + ½ tsp. turmeric + ¼ tsp. ginger + a pinch of black pepper
• Start omega-3s: 2g EPA+DHA/day at lunch
• Establish heart coherence: 3 times/day, 5 minutes

What you might feel: slight improvement in digestion and energy by the end of the week for some.

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Week 2: Enrich with dietary anti-inflammatory active ingredients

Goal: maximize polyphenol and antioxidant intake

• Add a serving of red berries daily (fresh or frozen)
• Include 2 to 3 servings of fatty fish per week (sardines, mackerel, herring)
• Steamed broccoli or cauliflower 3 times a week
• 2 to 3 cups of green tea per day (between meals, not during)
• Start curcumin supplementation: 500 mg/day at dinner

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Week 3: Amplify with targeted supplements

Goal: strengthen anti-inflammatory action systemically

• Add Boswellia: 300 mg morning and evening
• Introduce vitamin D3 if you are deficient (check your balance)
• 30 minutes of brisk walking per day, 5 days a week
• Sleep 7 to 8 hours with a fixed bedtime before 11 p.m.
• Reduce alcohol to less than 2 drinks per week

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Week 4: Evaluation and consolidation

Goal: measure progress, anchor habits sustainably

Evaluation Criterion	Before	After 4 weeks
Joint pain (score /10)	...	...
General fatigue (score /10)	...	...
Digestive quality (score /10)	...	...
Mental clarity (score /10)	...	...
Sleep quality (score /10)	...	...
General mood (score /10)	...	...

• Continue the protocol for at least 8 to 12 weeks for lasting effects on inflammatory markers
• Consider an ultra-sensitive CRP dosage before and after to objectify the results

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FAQ – Your most frequently asked questions about natural anti-inflammatory active ingredients

1. What is the most effective natural anti-inflammatory active ingredient?

There is no single answer; it depends on the type and location of the inflammation. Curcumin is the most well-documented overall. Boswellia is particularly effective for joints. Omega-3s are most indicated for cardiovascular and cerebral inflammation. The ideal is often a synergy between several active ingredients rather than a single "champion."

2. Can medicinal anti-inflammatory drugs (ibuprofen) be replaced by natural active ingredients?

Not in the acute phase or in case of severe pain; medications act faster in these cases. However, for low-grade chronic inflammation, combined natural active ingredients can be just as effective in the long term, with a much superior tolerance profile. Always consult your doctor before stopping any treatment.

3. Is curcumin effective alone or should it be combined?

Alone, curcumin has very low bioavailability; your body absorbs it very poorly. It is only effective when combined with piperine (black pepper) and lipids. Some formulas also use liposomal or phytosome technology (Meriva®) to further improve absorption.

4. Are there any contraindications to natural anti-inflammatory active ingredients?

Yes, and it is important. High-dose curcumin is contraindicated in cases of gallstones and can interact with anticoagulants. Boswellia is not recommended during pregnancy. High-dose omega-3s can increase bleeding time. Always consult a healthcare professional if you are taking medication.

5. How long does it take to see the effects of anti-inflammatory supplements?

For curcumin and boswellia on joint pain: 4 to 6 weeks. For omega-3s on blood inflammatory markers: 8 to 12 weeks. For overall dietary changes: the first effects on energy and digestion are often felt within 2 to 3 weeks.

6. Can an anti-inflammatory diet really lower CRP?

Yes, it is documented. A meta-analysis published in Nutrients (2020) showed that a Mediterranean-type diet, rich in polyphenols, omega-3s, and fiber, significantly reduced ultra-sensitive CRP levels after 8 to 12 weeks. Dietary changes are slow but real and lasting.

7. Can stress nullify the effects of an anti-inflammatory diet?

In part, yes. Chronic stress maintains permanent activation of NF-κB and pro-inflammatory cytokines that can counteract dietary benefits. That's why stress management is an integral part of a coherent anti-inflammatory strategy and not an optional "bonus."

8. What are the best accessible anti-inflammatory foods for everyday use?

Without strict hierarchy: canned sardines, walnuts, extra virgin olive oil, broccoli, blueberries (frozen are great), raw red onion, fresh ginger, green tea, turmeric + black pepper. Simple, inexpensive ingredients that can be effortlessly incorporated into everyday cooking.

9. Is chronic inflammation reversible?

Yes, in the vast majority of cases, and this is one of the most encouraging news in modern nutritional medicine. Studies show normalization of inflammatory markers in 3 to 6 months with well-conducted dietary and lifestyle changes. The sooner one acts, the easier the reversibility.

10. Should I have a blood test before starting?

It is not essential, but it is useful to objectify your progress. Ask your doctor for a dosage of ultra-sensitive CRP (hsCRP), vitamin D, and possibly the omega-6/omega-3 ratio. This will give you a basis for comparison in 3 months.

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Conclusion: Silent inflammation is fought with daily actions, not punctual remedies

Chronic inflammation does not build up overnight. It develops gradually, due to a diet too poor in antioxidants, unmanaged stress, and too few hours of sleep. And it is deconstructed in the same way, gradually, through the accumulation of good daily habits.

Natural anti-inflammatory active ingredients are not a magic solution. They are powerful tools, provided they are used consistently, over time, and in addition to an adapted lifestyle.

Start with the simplest thing tomorrow morning: a cup of green tea, a handful of walnuts, a drizzle of olive oil on your steamed vegetables. It is these actions, repeated every day, that truly transform your inflammatory terrain.

Need personalized advice to identify your priority anti-inflammatory active ingredients according to your profile? Cécile and Marie from Pleine Forme are here to guide you. 02.47.20.49.17

To learn more on our blog:

• 10 Anti-Inflammatory Infusions: Soothe your body naturally.

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⚠️ Disclaimer: The advice in this article is for informational purposes only. It does not replace personalized medical advice in any way, especially in cases of diabetes, medication use, or pregnancy. Consult your doctor before any changes or taking supplements.

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Sources

Aggarwal B.B. & Harikumar K.B. (2009). Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. International Journal of Biochemistry & Cell Biology, 41(1):40–59. PubMed

Calder P.C. (2017). Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochemical Society Transactions, 45(5):1105–1115. PubMed

Siddiqui M.Z. (2011). Boswellia serrata, a potential antiinflammatory agent. Indian Journal of Pharmaceutical Sciences, 73(3):255–261. PubMed

Meier-Ewert H.K. et al. (2004). Effect of sleep loss on C-Reactive protein, an inflammatory marker of cardiovascular risk. Journal of the American College of Cardiology, 43(4):678–683. PubMed

Minihane A.M. et al. (2015). Low-grade inflammation, diet composition and health: current research evidence and its translation. British Journal of Nutrition, 114(7):999–1012. PubMed

Ricker M.A. & Haas W.C. (2017). Anti-Inflammatory Diet in Clinical Practice: A Review. Nutrition in Clinical Practice, 32(3):318–325. PubMed

ANSES (2021). Update of nutritional benchmarks – fatty acids. Collective expert report. anses.fr